A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron

@article{Shih2004A1S,
  title={A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron},
  author={William M. Shih and Joel D. Quispe and Gerald F. Joyce},
  journal={Nature},
  year={2004},
  volume={427},
  pages={618-621}
}
Molecular self-assembly offers a means of spontaneously forming complex and well-defined structures from simple components. The specific bonding between DNA base pairs has been used in this way to create DNA-based nanostructures and to direct the assembly of material on the subnanometre to micrometre scale. In principle, large-scale clonal production of suitable DNA sequences and the directed evolution of sequence lineages towards optimized behaviour can be realized through exponential DNA… 
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846 Citations

Assembly and structural analysis of a covalently closed nano-scale DNA cage

TLDR
The design, construction and structural analysis of a covalently closed and stable 3D DNA structure with the connectivity of an octahedron that assembles from eight oligonucleotides with a yield of ∼30%.

Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra

TLDR
This work designs basic DNA building units in such a way that many copies of identical units assemble into larger three-dimensional structures, and tests this hierarchical self-assembly concept with DNA molecules that form three-point-star motifs, or tiles.

Single-stranded DNA and RNA origami

TLDR
The work here establishes that unimolecular DNA or RNA folding, similar to multicomponent self-assembly, is a fundamental, general, and practically tractable strategy for constructing user-specified and replicable nucleic acid nanostructures, and expands the design space and material scalability for bottom-up nanotechnology.

Synergistic self-assembly of RNA and DNA molecules

TLDR
A simple, general strategy for the de novo design of nanostructures in which the self-assembly of RNA strands is programmed by DNA strands to enable the integration of the precise programmability of DNA with the rich functionality of RNA.

An Overview of Structural DNA Nanotechnology

  • N. Seeman
  • Biology, Chemistry
    Molecular biotechnology
  • 2007
TLDR
Structural DNA Nanotechnology uses unusual DNA motifs to build target shapes and arrangements, leading to branched systems with many strands and multiple helical domains and the use of periodic arrays.

A new building block for DNA network formation by self-assembly and polymerase chain reaction

TLDR
This work presents a straightforward synthesis of a rigid DNA branching building block successfully used for the generation of DNA networks by self-assembly and network formation by enzymatic DNA synthesis, indicating that rather rigid DNA networks were formed.

Self-assembly of a DNA dodecahedron from 20 trisoligonucleotides with C(3h) linkers.

TLDR
A new generation of trisoligonucleotides is reported on and the feasibility of constructing a dodecahedron that reflects the basic symmetry of a virus was forseen for strategy III, but so far this has not been achieved by any strategy.

Structural DNA nanotechnology: an overview.

  • N. Seeman
  • Biology
    Methods in molecular biology
  • 2005
TLDR
Structural DNA nanotechnology appears to be at the cusp of a truly exciting explosion of applications, which can be expected to occur by the end of the current decade.

Kinetic DNA Self-Assembly: Simultaneously Co-folding Complementary DNA Strands into Identical Nanostructures.

DNA origami is a powerful method for constructing DNA nanostructures. It requires long single-stranded DNAs. The preparation of such long DNA strands is often quite tedious and has a limited…

Programming and preparing long single-stranded DNA with highly integrated sequence information for the self-assembly of DNA nanostructures

TLDR
The removal of the excess of staple strands yet still possessing a high yield of the desired shapes and the adaptiveness to single-stranded RNA origami hint a promising future of this new technique in biomedical and biomaterial applications.
...

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