A 1.5-megabase physical map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13.

@article{Wood1996A1P,
  title={A 1.5-megabase physical map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13.},
  author={Tony Wood and Eri S. Srivatsan and Rita Chakrabarti and Guangkun Ma and N Kuan and Ghassan J Samara and Michael J Higgins and T. B. Shows and Carey L. Johnson and Yu-Jui Yvonne Wan and E P Passaro and Mark P. Sawicki},
  journal={Genomics},
  year={1996},
  volume={38 2},
  pages={166-73}
}
Linkage analysis and loss of heterozygosity studies have shown that the gene responsible for the multiple endocrine neoplasia type-1 (MEN1) syndrome localizes to a small interval between D11S427 and D11S460 on chromosome 11q13. As an initial step to clone this tumor suppressor gene, our group is the first to map the MEN1 region physically using yeast artificial chromosome, bacterial artificial chromosome (BAC), and cosmid contigs. The 1.5-Mb high-resolution, contiguous map extends from PYGM to… CONTINUE READING