A -1 frameshift in the HIV-1 env gene is enhanced by arginine deficiency via a hungry codon mechanism.

Abstract

Ribosomal frameshifting is used by various organisms to maximize protein coding potential of genomic sequences. It is commonly exploited by RNA viruses to overcome the constraint of their limited genome size. Frameshifting requires specific RNA structural features, such as a suitable heptanucleotide "slippery" sequence and an RNA pseudoknot. Previous… (More)

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