A 1,4-diphenyl-1,2,3-triazole-based β-turn mimic constructed by click chemistry.

Abstract

A series of 1,4-diphenyl-1,2,3-triazole-incorporated amide derivatives have been designed and prepared. X-ray crystallographic and (1D and 2D) (1)H NMR studies reveal that these compounds fold into stable U-shaped conformations driven by three-center intramolecular C-H···O hydrogen-bonding formed between the triazole C-5 H atom and the two ether O atoms… (More)
DOI: 10.1021/jo300063u

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