A “Primer”-Based Mechanism Underlies Branched Actin Filament Network Formation and Motility

@article{Achard2010AM,
  title={A “Primer”-Based Mechanism Underlies Branched Actin Filament Network Formation and Motility},
  author={V{\'e}rane Achard and Jean-Louis Martiel and Alph{\'e}e Michelot and Christophe Gu{\'e}rin and Anne-C{\'e}cile Reymann and Laurent Blanchoin and Rajaa Boujemaa-Paterski},
  journal={Current Biology},
  year={2010},
  volume={20},
  pages={423-428}
}
Cells use actin assembly to generate forces for membrane protrusions during movement [1] or, in the case of pathogens, to propel themselves in the host cells, in crude extracts [2], or in mixtures of actin and other purified proteins [3]. Significant progress has been made in understanding the mechanism of actin-based motility at a macroscopic level by using biomimetic systems in vitro [4-6]. Here, we combined such a system with evanescent wave microscopy to visualize Arp2/3-mediated actin… CONTINUE READING

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