A ‘single toxin–double lesion’ rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis

@article{Ghorayeb2002AT,
  title={A ‘single toxin–double lesion’ rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis},
  author={Imad Ghorayeb and P. O. Fernagut and L. Hervier and Bertrand Labattu and Francois Tison},
  journal={Neuroscience},
  year={2002},
  volume={115},
  pages={533-546}
}
Previous attempts to reproduce striatonigral degeneration, the core pathology underlying Parkinsonism in multiple system atrophy, have been impeded by interactions in the neurotoxins used to replicate striatal and nigral degeneration in rodents. To overcome these interactions, we have developed a new model of striatonigral degeneration which uses a single unilateral administration of 1-methyl-4-phenylpyridinium ion (MPP(+)) into the rat striatum. Spontaneous and drug-induced rotational… CONTINUE READING

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