A ‘GAG’ reflex prevents repair of the damaged CNS

  title={A ‘GAG’ reflex prevents repair of the damaged CNS},
  author={Larry S. Sherman and Stephen A Back},
  journal={Trends in Neurosciences},
The extracellular matrix of the central nervous system (CNS) serves as both a supporting structure for cells and a rich source of signaling molecules that can influence cell proliferation, survival, migration and differentiation. A large proportion of this matrix is composed of proteoglycans--proteins with long chains of polysaccharides, called glycosaminoglycans (GAGs), covalently attached. Although many of the activities of proteoglycans depend on their core proteins, GAGs themselves can… CONTINUE READING


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