A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior

  title={A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior},
  author={J E Beaulieu and Sebastien Nicolas Marion and Ramona Marie Rodriguiz and Ivan O. Medvedev and Tatyana D. Sotnikova and Valentina Ghisi and William C. Wetsel and Robert J Lefkowitz and Raul R Gainetdinov and Marc G. Caron},
Besides their role in desensitization, beta-arrestin 1 and 2 promote the formation of signaling complexes allowing G protein-coupled receptors (GPCR) to signal independently from G proteins. Here we show that lithium, a pharmacological agent used for the management of psychiatric disorders such as bipolar disorder, schizophrenia, and depression, regulates Akt/glycogen synthase kinase 3 (GSK3) signaling and related behaviors in mice by disrupting a signaling complex composed of Akt, beta… CONTINUE READING
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