A [+18RGD] protamine variant for nontoxic and effective reversal of conventional heparin and low-molecular-weight heparin anticoagulation.

@article{Wakefield1996AP,
  title={A [+18RGD] protamine variant for nontoxic and effective reversal of conventional heparin and low-molecular-weight heparin anticoagulation.},
  author={Thomas W. Wakefield and Philip C. Andrews and Shirley K. Wrobleski and Amy M. Kadell and Sheela Tejwani and M S Hulin and James C. Stanley},
  journal={The Journal of surgical research},
  year={1996},
  volume={63 1},
  pages={280-6}
}
Protamine sulfate reversal of heparin anticoagulation causes adverse side effects. Additionally, protamine sulfate is relatively ineffective at reversing factor Xa inhibition caused by low-molecular weight heparin (LMWH, Enoxaparin). Previously, a +18 compound partially reversed heparin and LMWH with minimal toxicity. In the present study, a new +18… CONTINUE READING