A 'Collagen Hug' model for Staphylococcus aureus CNA binding to collagen.

  title={A 'Collagen Hug' model for Staphylococcus aureus CNA binding to collagen.},
  author={Yinong Zong and Yi Xu and Xiaowen Liang and Douglas R. Keene and Agneta H{\"o}{\"o}k and Shivasankarappa Gurusiddappa and Magnus H{\"o}{\"o}k and Sthanam V. L. Narayana},
  journal={The EMBO journal},
  volume={24 24},
The structural basis for the association of eukaryotic and prokaryotic protein receptors and their triple-helical collagen ligand remains poorly understood. Here, we present the crystal structures of a high affinity subsegment of the Staphylococcus aureus collagen-binding CNA as an apo-protein and in complex with a synthetic collagen-like triple helical peptide. The apo-protein structure is composed of two subdomains (N1 and N2), each adopting a variant IgG-fold, and a long linker that connects… CONTINUE READING

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