A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells.

  title={A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells.},
  author={Mar{\'i}a I. Lioudyno and Hakim Hiel and Jee-Hyun Kong and Eleonora Katz and Erik H Waldman and Suchitra Parameshwaran-Iyer and Elisabeth Glowatzki and Paul Albert Fuchs},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={24 49},
Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell. It has been proposed that calcium-induced calcium release (CICR) from a near-membrane postsynaptic store supplements this process. Here, we demonstrate expression of type I ryanodine receptors in outer hair cells in the apical turn of the rat cochlea… CONTINUE READING

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