A "partitioned leaping" approach for multiscale modeling of chemical reaction dynamics.

@article{Harris2006AL,
  title={A "partitioned leaping" approach for multiscale modeling of chemical reaction dynamics.},
  author={Leonard A. Harris and Paulette Clancy},
  journal={The Journal of chemical physics},
  year={2006},
  volume={125 14},
  pages={
          144107
        }
}
We present a novel multiscale simulation approach for modeling stochasticity in chemical reaction networks. The approach seamlessly integrates exact-stochastic and "leaping" methodologies into a single partitioned leaping algorithmic framework. The technique correctly accounts for stochastic noise at significantly reduced computational cost, requires the definition of only three model-independent parameters, and is particularly well suited for simulating systems containing widely disparate… CONTINUE READING

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