A "latent niche" mechanism for tumor initiation.

  title={A "latent niche" mechanism for tumor initiation.},
  author={Marie McGovern and Roumen Voutev and John Maciejowski and Ann K. Corsi and E. Jane Albert Hubbard},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 28},
Stem cells, their niches, and their relationship to cancer are under intense investigation. Because tumors and metastases acquire self-renewing capacity, mechanisms for their establishment may involve cell-cell interactions similar to those between stem cells and stem cell niches. On the basis of our studies in Caenorhabditis elegans, we introduce the concept of a "latent niche" as a differentiated cell type that does not normally contact stem cells nor act as a niche but that can, under… CONTINUE READING

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