Aβ42 Is Essential for Parenchymal and Vascular Amyloid Deposition in Mice

@article{McGowan2005A42IE,
  title={Aβ42 Is Essential for Parenchymal and Vascular Amyloid Deposition in Mice},
  author={Eileen McGowan and Fiona Pickford and Jungsu Kim and Luisa Onstead and Jason L Eriksen and Cindy Yu and Lisa M Skipper and Michael P Murphy and Jenny Beard and Pritam Das and Karen R Jansen and Michael W Delucia and Wen-lang Lin and Georgia Dolios and Rong Wang and Christopher B. Eckman and Dennis W. Dickson and Mike Hutton and John S. Hardy and Todd E Golde},
  journal={Neuron},
  year={2005},
  volume={47},
  pages={191-199}
}
Considerable circumstantial evidence suggests that Abeta42 is the initiating molecule in Alzheimer's disease (AD) pathogenesis. However, the absolute requirement for Abeta42 for amyloid deposition has never been demonstrated in vivo. We have addressed this by developing transgenic models that express Abeta1-40 or Abeta1-42 in the absence of human amyloid beta protein precursor (APP) overexpression. Mice expressing high levels of Abeta1-40 do not develop overt amyloid pathology. In contrast… CONTINUE READING
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