Aβ1-15/16 as a Potential Diagnostic Marker in Neurodegenerative Diseases

Abstract

Cerebrospinal fluid (CSF) biomarkers for Alzheimer’s disease (AD) reflect brain biochemistry. Using combined immunoprecipitation and mass spectrometry, we have shown that amyloid beta 1-15 (Aβ1-15) is produced by concerted β- and α-secretase cleavage of amyloid precursor protein (APP) and that the relative levels of Aβ1-16 in AD compared to controls are… (More)
DOI: 10.1007/s12017-012-8208-8

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@article{Nutu2012A11516AA, title={Aβ1-15/16 as a Potential Diagnostic Marker in Neurodegenerative Diseases}, author={Magdalena Nutu and Philippe Bourgeois and Henrik Zetterberg and Erik Portelius and Ulf Andr{\'e}asson and St{\'e}phane Parent and Francesco Lipari and Sara M. Hall and Radu Constantinescu and Oskar Hansson and Kaj Blennow}, journal={NeuroMolecular Medicine}, year={2012}, volume={15}, pages={169-179} }