Aβ peptides and calcium influence secretion of the amyloid protein precursor from chick sympathetic neurons in culture

@article{Mok2000APA,
  title={Aβ peptides and calcium influence secretion of the amyloid protein precursor from chick sympathetic neurons in culture},
  author={S. Mok and A. Clippingdale and K. Beyreuther and C. Masters and C. Barrow and D. Small},
  journal={Journal of Neuroscience Research},
  year={2000},
  volume={61}
}
  • S. Mok, A. Clippingdale, +3 authors D. Small
  • Published 2000
  • Biology, Medicine
  • Journal of Neuroscience Research
  • The major constituent of amyloid plaques in the Alzheimer disease (AD) brain is the amyloid protein (Aβ). Aβ has been shown to be neurotoxic to cells, but the exact mechanism of its effects are still not known. Most studies have focussed on Aβ neurotoxicity, but little is known about the effect of Aβ peptides on cellular protein metabolism and secretion. To examine the effect of Aβ peptides on APP secretion, chick sympathetic neurons were metabolically labeled with [35S]methionine and the… CONTINUE READING
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