Aβ oligomer toxicity inhibitor protects memory in models of synaptic toxicity.

@article{Scopes2012AOT,
  title={Aβ oligomer toxicity inhibitor protects memory in models of synaptic toxicity.},
  author={David I C Scopes and Eugene O'Hare and Ross D Jeggo and Andrew D Whyment and D Spanswick and E-M Kim and Joseph Gannon and Hozefa Amijee and Joseph M. Colacino Pushkar N. Kaul Vera M. Kolb J. Mark Treherne},
  journal={British journal of pharmacology},
  year={2012},
  volume={167 2},
  pages={383-92}
}
BACKGROUND AND PURPOSE Amyloid-β (Aβ) aggregation into synaptotoxic, prefibrillar oligomers is a major pathogenic event underlying the neuropathology of Alzheimer's disease (AD). The pharmacological and neuroprotective properties of a novel Aβ aggregation inhibitor, SEN1269, were investigated on aggregation and cell viability and in test systems relevant to synaptic function and memory, using both synthetic Aβ(1-42) and cell-derived Aβ oligomers. EXPERIMENTAL APPROACH Surface plasmon… CONTINUE READING

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