Aβ induces PUMA activation: a new mechanism for Aβ-mediated neuronal apoptosis.

@article{Feng2015AIP,
  title={Aβ induces PUMA activation: a new mechanism for Aβ-mediated neuronal apoptosis.},
  author={Jie Feng and Chengbo Meng and Da Xing},
  journal={Neurobiology of aging},
  year={2015},
  volume={36 2},
  pages={789-800}
}
p53 upregulated modulator of apoptosis (PUMA) is a promising tumor therapy target because it elicits apoptosis and profound sensitivity to radiation and chemotherapy. However, inhibition of PUMA may be beneficial for curbing excessive apoptosis associated with neurodegenerative disorders. Alzheimer's disease (AD) is a representative neurodegenerative disease in which amyloid-β (Aβ) deposition causes neurotoxicity. The regulation of PUMA during Aβ-induced neuronal apoptosis remains poorly… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS