Aβ increases neural stem cell activity in senescence-accelerated SAMP8 mice.

@article{DazMoreno2013AIN,
  title={Aβ increases neural stem cell activity in senescence-accelerated SAMP8 mice.},
  author={Mar{\'i}a D{\'i}az-Moreno and Rafael Hortig{\"u}ela and Ania Gonçalves and Irmina Garc{\'i}a-Carpio and Gemma Manich and Edurne Garc{\'i}a-Berm{\'u}dez and Mireia Moreno-Estell{\'e}s and C{\'e}sar Eguiluz and Jordi Vilaplana and Carme Pelegr{\'i} and Marçal Vilar and Helena Mira},
  journal={Neurobiology of aging},
  year={2013},
  volume={34 11},
  pages={2623-38}
}
Neurogenesis persists in the adult brain as a form of plasticity due to the existence of neural stem cells (NSCs). Alterations in neurogenesis have been found in transgenic Alzheimer's disease (AD) mouse models, but NSC activity and neurogenesis in sporadic AD models remains to be examined. We herein describe a remarkable increase in NSC proliferation in the forebrain of SAMP8, a non-transgenic mouse strain that recapitulates the transition from healthy aging to AD. The increase in… CONTINUE READING