Aβ and human amylin share a common toxicity pathway via mitochondrial dysfunction

@article{Lim2010AAH,
  title={A$\beta$ and human amylin share a common toxicity pathway via mitochondrial dysfunction},
  author={Y. A. Lim and Virginie F. Rhein and Ginette Baysang and Fides Meier and Anne Poljak and Mark J. Raftery and Michael Guilhaus and Lars M. Ittner and Anne Eckert and J{\"u}rgen G{\"o}tz},
  journal={PROTEOMICS},
  year={2010},
  volume={10}
}
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are leading causes of morbidity and mortality in the elderly. Both diseases are characterized by amyloid deposition in target tissues: aggregation of amylin in T2DM is associated with loss of insulin‐secreting β‐cells, while amyloid β (Aβ) aggregation in AD brain is associated with neuronal loss. Here, we used quantitative iTRAQ proteomics as a discovery tool to show that both Aβ and human amylin (HA) deregulate identical proteins, a… 
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