Aβ and human amylin share a common toxicity pathway via mitochondrial dysfunction

@article{Lim2010AAH,
  title={A$\beta$ and human amylin share a common toxicity pathway via mitochondrial dysfunction},
  author={Y. Lim and V. Rhein and G. Baysang and F. Meier and A. Poljak and Mark J. Raftery and M. Guilhaus and L. Ittner and A. Eckert and J. G{\"o}tz},
  journal={PROTEOMICS},
  year={2010},
  volume={10}
}
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are leading causes of morbidity and mortality in the elderly. Both diseases are characterized by amyloid deposition in target tissues: aggregation of amylin in T2DM is associated with loss of insulin‐secreting β‐cells, while amyloid β (Aβ) aggregation in AD brain is associated with neuronal loss. Here, we used quantitative iTRAQ proteomics as a discovery tool to show that both Aβ and human amylin (HA) deregulate identical proteins, a… Expand
Islet Amyloid Polypeptide: A Partner in Crime With Aβ in the Pathology of Alzheimer's Disease
Insights into mitochondrial dysfunction: aging, amyloid-β, and tau-A deleterious trio.
Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress.
Inhibition of the Mitochondrial Enzyme ABAD Restores the Amyloid-β-Mediated Deregulation of Estradiol
Amylin Receptor: A Common Pathophysiological Target in Alzheimer’s Disease and Diabetes Mellitus
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 82 REFERENCES
Amyloid β-induced Changes in Nitric Oxide Production and Mitochondrial Activity Lead to Apoptosis*
Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice
Increased susceptibility to amyloid toxicity in familial Alzheimer's fibroblasts
Oligomeric and fibrillar species of β-amyloid (Aβ42) both impair mitochondrial function in P301L tau transgenic mice
Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
...
1
2
3
4
5
...