Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine*

@article{Felice2007AOI,
  title={Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine*},
  author={F. D. De Felice and P. Velasco and M. Lambert and K. Viola and S. Fern{\'a}ndez and S. T. Ferreira and W. Klein},
  journal={Journal of Biological Chemistry},
  year={2007},
  volume={282},
  pages={11590 - 11601}
}
  • F. D. De Felice, P. Velasco, +4 authors W. Klein
  • Published 2007
  • Medicine, Chemistry
  • Journal of Biological Chemistry
  • Oxidative stress is a major aspect of Alzheimer disease (AD) pathology. We have investigated the relationship between oxidative stress and neuronal binding of Aβ oligomers (also known as ADDLs). ADDLs are known to accumulate in brain tissue of AD patients and are considered centrally related to pathogenesis. Using hippocampal neuronal cultures, we found that ADDLs stimulated excessive formation of reactive oxygen species (ROS) through a mechanism requiring N-methyl-d-aspartate receptor (NMDA-R… CONTINUE READING
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