Aβ Internalization by Neurons and Glia

  title={Aβ Internalization by Neurons and Glia},
  author={Amany S Mohamed and Elena I Posse de Chaves},
  booktitle={International journal of Alzheimer's disease},
In the brain, the amyloid β peptide (Aβ) exists extracellularly and inside neurons. The intracellular accumulation of Aβ in Alzheimer's disease brain has been questioned for a long time. However, there is now sufficient strong evidence indicating that accumulation of Aβ inside neurons plays an important role in the pathogenesis of Alzheimer's disease. Intraneuronal Aβ originates from intracellular cleavage of APP and from Aβ internalization from the extracellular milieu. We discuss here the… CONTINUE READING

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