Aβ(1-42) aggregates into non-toxic amyloid assemblies in the presence of the natural polyphenol oleuropein aglycon.

@article{Rigacci2011A142AI,
  title={A$\beta$(1-42) aggregates into non-toxic amyloid assemblies in the presence of the natural polyphenol oleuropein aglycon.},
  author={S. Rigacci and Valentina Guidotti and M. Bucciantini and Daniela Nichino and A. Relini and A. Berti and M. Stefani},
  journal={Current Alzheimer research},
  year={2011},
  volume={8 8},
  pages={
          841-52
        }
}
Amyloid aggregation starts with the initial misfolding of peptide/protein precursors, with subsequent structural rearrangement into oligomers and protofibrils; the latter eventually organize into fibrils with shared basic structural features, found deposited in amyloid diseases. Mounting evidence indicates early oligomers as the most toxic amyloid species; accordingly, the search of inhibitors of their growth is considered a promising target to prevent amyloid toxicity. We recently showed that… Expand
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