9p24 abnormalities in hematologic malignancies with a focus on diffuse large B-cell lymphoma.

@article{Patel20179p24AI,
  title={9p24 abnormalities in hematologic malignancies with a focus on diffuse large B-cell lymphoma.},
  author={Dilan A Patel and Andrew W Hahn and Mike G Martin},
  journal={Medical oncology},
  year={2017},
  volume={34 5},
  pages={95}
}
Chromosome 9p24 contains four genes that are critical for immune evasion and propagating cell growth. Two of the genes, PD-L1 and PD-L2, interact with the PD-1 receptor on the surface of T cells to attenuate immune surveillance by decreasing T-cell activation and altering the tumor microenvironment [1]. Accordingly, the PDL axis has become an attractive… CONTINUE READING