99mTc sestamibi imaging - can it be a useful substitute for hepatobiliary scintigraphy in infantile jaundice?

@article{Sadeghi200999mTcSI,
  title={99mTc sestamibi imaging - can it be a useful substitute for hepatobiliary scintigraphy in infantile jaundice?},
  author={Ramin Sadeghi and Hamidreza Kianifar and Vahid Reza Dabbagh Kakhki and Seyyed Rasoul Zakavi and Kianoush Ansari},
  journal={Nuklearmedizin. Nuclear medicine},
  year={2009},
  volume={48 3},
  pages={
          100-3
        }
}
AIM Hepatobiliary scintigraphy is an integral part in the diagnostic work-up of the neonatal cholestasis syndrome. However, less than optimal specificity is its major disadvantage. Differentiation between biliary atresia and neonatal hepatitis is nearly impossible in some cases with poor hepatocellular function. 99mTc sestamibi (MIBI) is a cationic lipophilic agent which is a substrate of P-glycoprotein. This glycoprotein is normally expressed in biliary canalicular surfaces of hepatocytes… 
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Accuracy of hepatobiliary scintigraphy for differentiation of neonatal hepatitis from biliary atresia: systematic review and meta-analysis of the literature
TLDR
It is concluded that hepatobiliary scintigraphy using IDA derivatives can be very useful for diagnostic work-up of neonatal cholestasis and non-imaging methods seem to be promising and warrant further validation.
Application of ursodeoxycholic acid in hepatobiliary scintigraphy for neonatal hyperbilirubinemia: Comparison with phenobarbital
TLDR
Ursodeoxycholic acid is a safe and efficient drug for pre-treatment of patients with neonatal cholestasis syndrome who are going to undergo hepatobiliary scintigraphy, which has fewer complications and is more efficient than phenobarbital.
Drug augmented hepatobiliary scintigraphy for evaluation of neonatal cholestasis: what does the evidence point to?
  • R. Sadeghi
  • Medicine
    Nuclear medicine communications
  • 2015
TLDR
The study by Malik and colleagues was a unique randomized controlled trial on cholestatic infants that used nonexcretory nonaugmented hepatobiliary scintigraphy to compare phenobarbital (PB) and ursodexoycholic (UDC).

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