99mTc-labeled vasopressin peptide as a radiopharmaceutical for small-cell lung cancer (SCLC) diagnosis.

@article{Gniazdowska201499mTclabeledVP,
  title={99mTc-labeled vasopressin peptide as a radiopharmaceutical for small-cell lung cancer (SCLC) diagnosis.},
  author={Ewa Gniazdowska and Przemysław Koźmiński and Krzysztof Bańkowski and Paweł Ochman},
  journal={Journal of medicinal chemistry},
  year={2014},
  volume={57 14},
  pages={5986-94}
}
The 99mTc-labeled conjugates of the vasopressin (AVP) peptide and of its analogue d(CH2)5[D-Tyr(Et2)-Ile4-Eda9]AVP (AVP(an)) have been synthesized using the technetium complexes with tetradentate tripodal chelator (the tris(2-mercaptoethyl)amine (NS3)) and the monodentate isocyanide ligand (CN-peptide). The conjugates exhibit high stability in the presence of 100 times the molar excess of standard amino acids cysteine or histidine and also satisfactory stability in human serum. The 99mTc(NS3… CONTINUE READING

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