99mTc labeled VIP analog: evaluation for imaging colorectal cancer.

  title={99mTc labeled VIP analog: evaluation for imaging colorectal cancer.},
  author={P. Sambasiva Rao and Mathew L. Thakur and V R Pallela and Ratnakar Patti and Kesava Reddy and Hongxun Li and Sameer Sharma and Hoang H. P. L. Pham and Linda Diggles and Chiyoko Minami and Carol S. Marcus},
  journal={Nuclear medicine and biology},
  volume={28 4},
Early and reliable diagnosis of colorectal cancer continues to be demanding and challenging. Colorectal cancer cells express Vasoactive Intestinal Peptide (VIP) receptors in high density. We have prepared a VIP analog (TP3654), labeled it with (99m)Tc, and evaluated it in experimental animals as an agent for imaging colorectal cancer. The tissue distribution of (99m)Tc-TP3654 has been compared with that of (111)In-DTPA-Octreotide and (99m)Tc-anti-CEA scan in nude mice bearing human colorectal… CONTINUE READING


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