99mTc-Labeled HYNIC-DAPI Causes Plasmid DNA Damage with High Efficiency

@inproceedings{Kotzerke201499mTcLabeledHC,
  title={99mTc-Labeled HYNIC-DAPI Causes Plasmid DNA Damage with High Efficiency},
  author={J{\"o}rg Kotzerke and Robert Punzet and Roswitha Runge and Sandra Ferl and Liane Oehme and Gerd Wunderlich and R. Freudenberg},
  booktitle={PloS one},
  year={2014}
}
(99m)Tc is the standard radionuclide used for nuclear medicine imaging. In addition to gamma irradiation, (99m)Tc emits low-energy Auger and conversion electrons that deposit their energy within nanometers of the decay site. To study the potential for DNA damage, direct DNA binding is required. Plasmid DNA enables the investigation of the unprotected… CONTINUE READING