99Tcm-labelled meso-HMPAO and glutathione content of human lung tumours.

  title={99Tcm-labelled meso-HMPAO and glutathione content of human lung tumours.},
  author={N. P. Rowell and V. R. McCready and B. Cronin and J. Pepper and B. Higley and J. F. Burke and D. Tyrrell},
  journal={Nuclear medicine communications},
  volume={10 7},
Levels of reduced glutathione (GSH) are increased in some types of malignant tumours and are known to influence the response to radio- and chemotherapy. In vitro studies suggest a correlation between cellular GSH concentration and retention of the meso form of hexamethyl propyleneamineoxime (HMPAO). This study investigates the relationship between in vivo tissue retention of 99Tcm-labelled HMPAO and GSH concentration in ten patients referred for thoracotomy for possible lung cancer. Retention… Expand
Intracellular metabolism of 99mTc-d,l-HMPAO in vitro: a basic approach for understanding the hyperfixation mechanism in damaged brain.
The mechanism of technetium-99m-labeled d,l-hexamethylpropylene amine oxime hyperfixation in damaged brain was elucidated using in vitro metabolic studies, and 99mTc-HMPAO might be metabolized by mitochondrial SH compound(s) exhibiting strong reductant activity, andhyperfixation might be an indication of mitochondrial damage of the brain. Expand
Glutathione-responsive biodegradable polyurethane nanoparticles for lung cancer treatment.
  • R. Iyer, Tam Nguyen, +4 authors Yi Hong
  • Medicine, Chemistry
  • Journal of controlled release : official journal of the Controlled Release Society
  • 2020
These nanoparticles developed using a GSH-cleavable disulfide bond containing polyurethane that responds to elevated levels of GSH within lung cancer cells have potential to be used for on-demand drug release for an enhanced chemotherapy to effectively treat lung cancer. Expand
Redox imaging of inflammation in asthma.
It is identified that the airway epithelium of patients with asthma is shifted to greater reducing potential, recognized by a higher ratio of reduced to oxidized glutathione, which occurs in response to the episodic oxidative inflammation of asthma. Expand
Glutathione levels in human tumors
Clinical studies in which glutathione was measured in tumor tissue from patients with brain, breast, gastrointestinal, gynecological, head and neck and lung cancer are summarized and approaches that may improve the clinical value of glutATHione as a biomarker are recommended. Expand
The development of new radiopharmaceuticals
  • K. Britton
  • Chemistry, Medicine
  • European Journal of Nuclear Medicine
  • 2004
The development of new radiopharmaceuticals is the basis of the continuing growth of nuclear medicine and so much damage to this developing biological field is being done by regulatory authorities that one must ask who should or can regulate the regulators. Expand
A toxicokinetic model for styrene and its metabolite styrene-7,8-oxide in mouse, rat and human with special emphasis on the lung.
There was no dramatic difference in the calculated average pulmonary SO burden between both animal species, however, pulmonary GSH loss was by far more expressed in ST exposed mice than rats, which the model considers to be useful for estimating the risk resulting from exposure to ST. Expand
The fate of administered radiopharmaceuticals
The biologic fate of administered radiopharmaceutical is depicted in Figure 5.1 and depends mostly on distribution and elimination because most radiopharmaceuticals are administered by intravenousExpand
Physiologically based pharmacokinetic model parameter estimation and sensitivity and variability analyses for acrylonitrile disposition in humans.
While many parameters contributed to the estimated variability of the model predictions, the reaction rate of CEO with glutathione, hydrolysis rate for CEO, and blood:brain partition coefficient of CEO were the parameters predicted to make the greatest contributions to variability of blood and brain CEO concentrations in humans. Expand
Separation of the Stereoisomers of Hexamethyl-Propyleneamine Oxime (HM-PAO) by High-Performance Liquid Chromatography
Abstract The Resolvosil BSA-7, Chiracel OD, and Chiralpak AD columns were examined to determine whether one might be suitable for the separation of enatiomers of the ligand hexamethyl-propyleneamineExpand
No role of DT‐diaphorase (NQO1) in the protection against oxidized quercetin
Q reacted much faster with glutathione or protein thiols than with DT‐diaphorase in experiments with isolated compounds as well as with human liver cytosol or blood plasma, indicating that DT‐ diaphorases has no role in the protection against QQ. Expand