99Tcm-labelled meso-HMPAO and glutathione content of human lung tumours.

  title={99Tcm-labelled meso-HMPAO and glutathione content of human lung tumours.},
  author={Neal P. Rowell and V. Ralph McCready and Bernadette F. Cronin and Jonathan Pepper and Brian Higley and Johnj . Burke and David Arthur John Tyrrell},
  journal={Nuclear medicine communications},
  volume={10 7},
Levels of reduced glutathione (GSH) are increased in some types of malignant tumours and are known to influence the response to radio- and chemotherapy. In vitro studies suggest a correlation between cellular GSH concentration and retention of the meso form of hexamethyl propyleneamineoxime (HMPAO). This study investigates the relationship between in vivo tissue retention of 99Tcm-labelled HMPAO and GSH concentration in ten patients referred for thoracotomy for possible lung cancer. Retention… 

Glutathione-responsive biodegradable polyurethane nanoparticles for lung cancer treatment.

  • R. IyerTam Nguyen Yi Hong
  • Biology, Chemistry
    Journal of controlled release : official journal of the Controlled Release Society
  • 2020

Redox imaging of inflammation in asthma.

It is identified that the airway epithelium of patients with asthma is shifted to greater reducing potential, recognized by a higher ratio of reduced to oxidized glutathione, which occurs in response to the episodic oxidative inflammation of asthma.

Glutathione levels in human tumors

Clinical studies in which glutathione was measured in tumor tissue from patients with brain, breast, gastrointestinal, gynecological, head and neck and lung cancer are summarized and approaches that may improve the clinical value of glutATHione as a biomarker are recommended.

The development of new radiopharmaceuticals

  • K. Britton
  • Biology
    European Journal of Nuclear Medicine
  • 2004
The development of new radiopharmaceuticals is the basis of the continuing growth of nuclear medicine and so much damage to this developing biological field is being done by regulatory authorities that one must ask who should or can regulate the regulators.

The fate of administered radiopharmaceuticals

The biologic fate of administered radiopharmaceutical is depicted in Figure 5.1 and depends mostly on distribution and elimination because most radiopharmaceuticals are administered by intravenous

Physiologically based pharmacokinetic model parameter estimation and sensitivity and variability analyses for acrylonitrile disposition in humans.

While many parameters contributed to the estimated variability of the model predictions, the reaction rate of CEO with glutathione, hydrolysis rate for CEO, and blood:brain partition coefficient of CEO were the parameters predicted to make the greatest contributions to variability of blood and brain CEO concentrations in humans.

Separation of the Stereoisomers of Hexamethyl-Propyleneamine Oxime (HM-PAO) by High-Performance Liquid Chromatography

Abstract The Resolvosil BSA-7, Chiracel OD, and Chiralpak AD columns were examined to determine whether one might be suitable for the separation of enatiomers of the ligand hexamethyl-propyleneamine