99Tcm-labelled meso-HMPAO and glutathione content of human lung tumours.

  title={99Tcm-labelled meso-HMPAO and glutathione content of human lung tumours.},
  author={N. P. Rowell and V. R. McCready and B. Cronin and J. Pepper and B. Higley and J. F. Burke and D. Tyrrell},
  journal={Nuclear medicine communications},
  volume={10 7},
Levels of reduced glutathione (GSH) are increased in some types of malignant tumours and are known to influence the response to radio- and chemotherapy. In vitro studies suggest a correlation between cellular GSH concentration and retention of the meso form of hexamethyl propyleneamineoxime (HMPAO). This study investigates the relationship between in vivo tissue retention of 99Tcm-labelled HMPAO and GSH concentration in ten patients referred for thoracotomy for possible lung cancer. Retention… Expand
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