9-cis-retinoids: biosynthesis of 9-cis-retinoic acid.

@article{Paik20009cisretinoidsBO,
  title={9-cis-retinoids: biosynthesis of 9-cis-retinoic acid.},
  author={Jisun Paik and Silke Vogel and Roseann Piantedosi and Annemarie Sykes and William S. Blaner and Karen Swisshelm},
  journal={Biochemistry},
  year={2000},
  volume={39 27},
  pages={8073-84}
}
Retinoids function through conformational alterations of ligand-dependent nuclear transcription factors, the retinoic acid receptors, and retinoid X receptors. 9-cis-Retinoic acid is a known biological ligand for retinoid X receptors, but its synthesis pathway in vivo is largely unknown. Recently, we identified a cis-retinol dehydrogenase (cRDH) that oxidizes 9-cis-retinol to 9-cis-retinal. Since both the expression of cRDH mRNA and its substrate are found in liver, we studied 9-cis-retinol… CONTINUE READING

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