9-cis retinoic acid induces monocyte chemoattractant protein-1 secretion in human monocytic THP-1 cells.

@article{Zhu19999cisRA,
  title={9-cis retinoic acid induces monocyte chemoattractant protein-1 secretion in human monocytic THP-1 cells.},
  author={L. Zhu and Charles L. Bisgaier and Micheal Aviram and Roger Schofield Newton},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1999},
  volume={19 9},
  pages={
          2105-11
        }
}
Monocyte migration and activation are regulated by monocyte chemoattractant protein-1 (MCP-1). Prior studies have shown MCP-1 expression is modulated by a variety of ligands that act through extracellular receptors. In the current study, we show 9-cis retinoic acid (RA), a ligand for the nuclear hormone receptor retinoid X receptor (RXR) and retinoic acid receptor (RAR), markedly induces the expression of MCP-1. In human THP-1 monocytic leukemia cells cultured with RA (0.05 to 500 nmol/L), MCP… Expand
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