9-cis-Retinoic Acid and Troglitazone Impacts Cellular Adhesion, Proliferation, and Integrin Expression in K562 Cells

@article{Hanson20149cisRetinoicAA,
  title={9-cis-Retinoic Acid and Troglitazone Impacts Cellular Adhesion, Proliferation, and Integrin Expression in K562 Cells},
  author={Amanda Hanson and Jessica Gambill and Venusa Phomakay and Christina Staten and Melissa D Kelley},
  journal={PLoS ONE},
  year={2014},
  volume={9}
}
Retinoids are established pleiotropic regulators of both adaptive and innate immune responses. Recently, troglitazone, a PPAR gamma agonist, has been demonstrated to have anti-inflammatory effects. Separately, retinoids and troglitazone are implicated in immune related processes; however, their combinatory role in cellular adhesion and proliferation has not been well established. In this study, the effect of 9-cis-retinoic acid (9-cis-RA) and troglitazone on K562 cellular adhesion and… Expand
Retinoic acid receptor gamma impacts cellular adhesion, Alpha5Beta1 integrin expression and proliferation in K562 cells
TLDR
This study is the first to report that treatment with a RARγ specific agonist augments cellular adhesion to α5β1Integrin substrates, increases cell surface levels of the β1 integrin subunit, and dampens cellular proliferation in a time and concentration dependent manner in a human erythroleukemia cell line. Expand
Retinoids induce integrin-independent lymphocyte adhesion through RAR-α nuclear receptor activity.
TLDR
A battery of agonists and antagonists are employed to delineate the specific nuclear receptors utilized by retinoids to evoke lymphocyte cell adhesion to ADAM (adisintegrin and metalloprotease) protein family members and it is reported that RAR agonism is sufficient to promote immune cellAdhesion in both immortal and primary immune cells. Expand
9-cis-retinoic acid improves sensitivity to platelet-derived growth factor-BB via RXRα and SHP-1 in diabetic retinopathy.
TLDR
The vital roles of 9-cis-RA in improving sensitivity to PDGF-BB of retinal pericytes in DR are indicated, and basic evidences of new therapeutic targets like RXRα for further DR treatment are provided. Expand
Dual Regulation of L-Selectin-Mediated Leukocyte Adhesion by Endothelial Surface Glycocalyx
TLDR
The results demonstrate that the ESG layer serves a dual function: (1) on resting endothelium, it prevents leukocyte adhesion, and (2) under inflammatory conditions, it participates in endothelial-leukocyte interactions with molecules such as selectins. Expand
Pan-cancer analyses of the nuclear receptor superfamily.
TLDR
Nuclear receptors were uniquely and uniformly downregulated across all six tumor types, more than predicted by chance and each tumor type had a specific NR expression profile but these were most similar between breast and prostate cancer. Expand
The over-expression of aquaporin-1 alters erythroid gene expression in human erythroleukemia K562 cells
TLDR
It is demonstrated that AQP1 induced hemoglobins expression and altered erythroid gene expression by microarray analysis in K562 cells, and silencing of HEMGN by RNA interference inK562-AQP1 cells resulted in down-regulation of these genes. Expand

References

SHOWING 1-10 OF 90 REFERENCES
9-cis-retinoic acid promotes cell adhesion through integrin dependent and independent mechanisms across immune lineages.
TLDR
This study is the first to demonstrate that 9-cis-RA influences immune cell adhesion through at least two functionally distinct mechanisms, including established integrin receptors and a novel integrin-independent process. Expand
All-trans-retinoic acid induces integrin-independent B-cell adhesion to ADAM disintegrin domains.
TLDR
This study is the first to demonstrate that t-RA directly induces B cell adhesion in an integrin-independent manner and is not contingent upon t- RA metabolism, and to identify the retinoid that is functionally responsible for this augmented adhesion. Expand
All-trans-retinoic acid increased the expression of integrin alpha5beta1 and induced "anoikis" in SMMC-7721 hepatocarcinoma cell.
  • Y. Feng, L. Wang, +4 authors X. Zha
  • Chemistry, Medicine
  • Journal of experimental & clinical cancer research : CR
  • 2001
TLDR
Increased expression of integrin alpha5beta1 on the surface of SMMC 7721 hepatocarcinoma cell treated with 80 microM all-trans-retinoic acid, when unbound to Fn, would stop transducing survival signals to lead to "anoikis", and can be reverted by the interaction of integin alpha5 beta1 with Fn. Expand
All-trans-retinoic acid and Erk1/2 signaling synergistically regulate the expression of CD300B in human monocytic cells.
TLDR
The data suggest a model in which RA alone induces a CD300B mRNA response in which transcripts accumulate but remain untranslated and therefore "sterile," whereas RA combined with signals from the ERK1/2 pathway results in both increasedCD300B transcription and protein expression on the cell surface and in endocytic vesicles. Expand
Troglitazone, a PPAR-γ activator prevents endothelial cell adhesion molecule expression and lymphocyte adhesion mediated by TNF-α
TLDR
It is shown that troglitazone, an activator of the peroxisome proliferator-activated receptor-γ (PPAR-γ), widely used in the treatment of diabetes, has as well recently been highlighted as protective in models of inflammation and cancer, and may be useful in the clinical treatment of IBD. Expand
Retinoic acid upregulates beta(1)-integrin in vascular smooth muscle cells and alters adhesion to fibronectin.
  • M. Medhora
  • Biology, Medicine
  • American journal of physiology. Heart and circulatory physiology
  • 2000
TLDR
Results showed that modulation of vascular integrins by ATRA in adult rats contributes to functional changes that can cause remodeling of blood vessels. Expand
Peroxisome Proliferator-Activated Receptor γ-Mediated NF-κB Activation and Apoptosis in Pre-B Cells1
TLDR
Results suggest that activation of PPARγ-RXR initiates a potent apoptotic signaling cascade in B cells, potentially through NF-κB activation, and have implications for the nominal role of thePPARγ in B cell development and for the use of PParγ agonists as immunomodulatory therapeutics. Expand
All-trans and 9-cis retinoic acid enhance 1,25-dihydroxyvitamin D3-induced monocytic differentiation of U937 cells.
TLDR
Findings suggest that there is crossover of the nuclear signalling pathways of RA and D3, which may have clinical implications in that RA andD3 may be used in combination for differentiation-inducing therapy in acute myelogenous leukemia and myelodysplastic syndrome. Expand
The effect of differentiation inducers on the integrin expression of K562 erythroleukemia cells.
TLDR
It is shown, that an increased expression of a certain integrin does not necessarily lead to a comparable adhesion ability on its ligand in vitro, and the effects of differentiation‐inducers on the integrin profile and adhesive properties of K562 leukemia cells are studied. Expand
Peroxisome proliferator-activated receptor gamma-mediated NF-kappa B activation and apoptosis in pre-B cells.
TLDR
Results suggest that activation of PPARgamma-RXR initiates a potent apoptotic signaling cascade in B cells, potentially through NF-kappaB activation, and have implications for the nominal role of the PPARGamma in B cell development and for the use of PPargamma agonists as immunomodulatory therapeutics. Expand
...
1
2
3
4
5
...