9-cis-Retinoic Acid and Troglitazone Impacts Cellular Adhesion, Proliferation, and Integrin Expression in K562 Cells

  title={9-cis-Retinoic Acid and Troglitazone Impacts Cellular Adhesion, Proliferation, and Integrin Expression in K562 Cells},
  author={Amanda Hanson and Jessica Gambill and Venusa Phomakay and Christina Staten and Melissa D Kelley},
  journal={PLoS ONE},
Retinoids are established pleiotropic regulators of both adaptive and innate immune responses. Recently, troglitazone, a PPAR gamma agonist, has been demonstrated to have anti-inflammatory effects. Separately, retinoids and troglitazone are implicated in immune related processes; however, their combinatory role in cellular adhesion and proliferation has not been well established. In this study, the effect of 9-cis-retinoic acid (9-cis-RA) and troglitazone on K562 cellular adhesion and… Expand
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