9-cis β-Carotene Increased Cholesterol Efflux to HDL in Macrophages

  title={9-cis β-Carotene Increased Cholesterol Efflux to HDL in Macrophages},
  author={Sapir Bechor and Noa Zolberg Relevy and Ayelet Harari and Tal Almog and Yehuda Kamari and Ami Ben-Amotz and Dror Harats and Aviv Shaish},
Cholesterol efflux from macrophages is a key process in reverse cholesterol transport and, therefore, might inhibit atherogenesis. 9-cis-β-carotene (9-cis-βc) is a precursor for 9-cis-retinoic-acid (9-cis-RA), which regulates macrophage cholesterol efflux. Our objective was to assess whether 9-cis-βc increases macrophage cholesterol efflux and induces the expression of cholesterol transporters. Enrichment of a mouse diet with βc from the alga Dunaliella led to βc accumulation in peritoneal… CONTINUE READING