9-Phenanthrol inhibits recombinant and arterial myocyte TMEM16A channels.

@article{Burris20159PhenanthrolIR,
  title={9-Phenanthrol inhibits recombinant and arterial myocyte TMEM16A channels.},
  author={Sarah K. Burris and Qian Wang and Simon Bulley and Zachary P. Neeb and Jonathan H Jaggar},
  journal={British journal of pharmacology},
  year={2015},
  volume={172 10},
  pages={2459-68}
}
BACKGROUND AND PURPOSE In arterial smooth muscle cells (myocytes), intravascular pressure stimulates membrane depolarization and vasoconstriction (the myogenic response). Ion channels proposed to mediate pressure-induced depolarization include several transient receptor potential (TRP) channels, including TRPM4, and transmembrane protein 16A (TMEM16A), a Ca(2+) -activated Cl(-) channel (CaCC). 9-Phenanthrol, a putative selective TRPM4 channel inhibitor, abolishes myogenic tone in cerebral… CONTINUE READING

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TMEM16A channels

  • C Thomas-Gatewood, ZP Neeb, S Bulley, A Adebiyi, JP Bannister, MD Leo
  • 2011
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