9-NC-loaded folate-conjugated polymer micelles as tumor targeted drug delivery system: preparation and evaluation in vitro.

@article{Han20099NCloadedFP,
  title={9-NC-loaded folate-conjugated polymer micelles as tumor targeted drug delivery system: preparation and evaluation in vitro.},
  author={X. Han and J. Liu and Min Liu and Cao Xie and C. Zhan and Bing Gu and Y. Liu and L. Feng and W. Lu},
  journal={International journal of pharmaceutics},
  year={2009},
  volume={372 1-2},
  pages={
          125-31
        }
}
  • X. Han, J. Liu, +6 authors W. Lu
  • Published 2009
  • Medicine, Chemistry
  • International journal of pharmaceutics
  • In this study, folate-conjugated polymer micelles were synthesized by mixing folate-poly(ethylene glycol)-distearoylphosphatidylethanolamine (FA-PEG-DSPE) and methoxy-poly(ethylene glycol)-distearoylphosphatidylethanolamine (MPEG-DSPE) to encapsulate anticancer agent 9-nitro-camptothecin (9-NC). Formulations were characterized by critical micellization concentration (CMC) values of copolymers, micelle particle size, zeta-potential, encapsulation efficiency and drug loading efficiency. The molar… CONTINUE READING
    Isomeric folate-conjugated polymeric micelles bind to folate receptors and display anticancer effects.
    • 6
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