9-NC-loaded folate-conjugated polymer micelles as tumor targeted drug delivery system: preparation and evaluation in vitro.

@article{Han20099NCloadedFP,
  title={9-NC-loaded folate-conjugated polymer micelles as tumor targeted drug delivery system: preparation and evaluation in vitro.},
  author={Xue Han and Jing Liu and Min Liu and Cao Xie and Changyou Zhan and Bing Gu and Yu Liu and Linglin Feng and Weiyue Lu},
  journal={International journal of pharmaceutics},
  year={2009},
  volume={372 1-2},
  pages={
          125-31
        }
}
In this study, folate-conjugated polymer micelles were synthesized by mixing folate-poly(ethylene glycol)-distearoylphosphatidylethanolamine (FA-PEG-DSPE) and methoxy-poly(ethylene glycol)-distearoylphosphatidylethanolamine (MPEG-DSPE) to encapsulate anticancer agent 9-nitro-camptothecin (9-NC). Formulations were characterized by critical micellization concentration (CMC) values of copolymers, micelle particle size, zeta-potential, encapsulation efficiency and drug loading efficiency. The molar… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 15 references

Selectivity of folate conjugated polymer micelles against different tumor cells.

International journal of pharmaceutics • 2008
View 8 Excerpts
Highly Influenced

Preparation and characterization of polymeric micelles for solubilization of poorly soluble anticancer drugs

S. Zerrin, Y. Nilufer, B. Tamer
Eur. J. Pharm. Biopharm • 2006
View 2 Excerpts

Immunomicelles: targeted pharmaceutical carriers for poorly soluble drugs.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 3 Excerpts

Polymeric micelle for tumor pH and folate-mediated targeting.

Journal of controlled release : official journal of the Controlled Release Society • 2003
View 1 Excerpt

Biodegradable polymeric nanoparticles as drug delivery devices.

Journal of controlled release : official journal of the Controlled Release Society • 2001
View 1 Excerpt