9-Methyl-β-carboline-induced cognitive enhancement is associated with elevated hippocampal dopamine levels and dendritic and synaptic proliferation.

@article{Gruss20129MethylcarbolineinducedCE,
  title={9-Methyl-β-carboline-induced cognitive enhancement is associated with elevated hippocampal dopamine levels and dendritic and synaptic proliferation.},
  author={Michael Gruss and Dorothea Appenroth and Armin Flubacher and Christoph Enzensperger and Joerg Bock and Christian Fleck and Gabriele Gille and Katharina Braun},
  journal={Journal of neurochemistry},
  year={2012},
  volume={121 6},
  pages={924-31}
}
β-Carbolines (BCs) belong to the heterogenous family of carbolines, which have been found exogenously, that is, in various fruits, meats, tobacco smoke, alcohol and coffee, but also endogenously, that is, blood, brain and CSF. These exogenous and endogenous BCs and some of their metabolites can exert neurotoxic effects, however, an unexpected stimulatory effect of 9-methyl-β-carboline (9-me-BC) on dopaminergic neurons in primary mesencephalic cultures was recently discovered. The aim of the… CONTINUE READING
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