9-Hydroxy-6,7-dimethoxydalbergiquinol inhibits osteoclast differentiation through down-regulation of Akt, c-Fos and NFATc1.

  title={9-Hydroxy-6,7-dimethoxydalbergiquinol inhibits osteoclast differentiation through down-regulation of Akt, c-Fos and NFATc1.},
  author={J. Kim and Yoon-Hee Cheon and S. C. Kwak and J. Baek and Y. Kim and K. Yoon and Jaemin Oh and M. S. Lee},
  journal={International immunopharmacology},
  volume={20 1},
  • J. Kim, J. Kim, +6 authors M. S. Lee
  • Published 2014
  • Biology, Medicine
  • International immunopharmacology
  • Recently, natural plant-derived products have been recognized as one of the main sources for drug discovery and development in human disease. 9-Hydroxy-6,7-dimethoxydalbergiquinol (HDDQ) isolated from the heart wood of Dalbergia odorifera is widely used in oriental medicine, however, the pharmacological effect of HDDQ in osteoclast-associated diseases remains unknown. In this study, HDDQ dose-dependently inhibited the early stage of RANKL-mediated osteoclast differentiation in bone marrow… CONTINUE READING
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