9-Hydroxy-6,7-dimethoxydalbergiquinol inhibits osteoclast differentiation through down-regulation of Akt, c-Fos and NFATc1.

@article{Kim20149Hydroxy67dimethoxydalbergiquinolIO,
  title={9-Hydroxy-6,7-dimethoxydalbergiquinol inhibits osteoclast differentiation through down-regulation of Akt, c-Fos and NFATc1.},
  author={J. Kim and Yoon-Hee Cheon and S. C. Kwak and J. Baek and Y. Kim and K. Yoon and Jaemin Oh and M. S. Lee},
  journal={International immunopharmacology},
  year={2014},
  volume={20 1},
  pages={
          213-20
        }
}
  • J. Kim, J. Kim, +6 authors M. S. Lee
  • Published 2014
  • Biology, Medicine
  • International immunopharmacology
    • Recently, natural plant-derived products have been recognized as one of the main sources for drug discovery and development in human disease. 9-Hydroxy-6,7-dimethoxydalbergiquinol (HDDQ) isolated from the heart wood of Dalbergia odorifera is widely used in oriental medicine, however, the pharmacological effect of HDDQ in osteoclast-associated diseases remains unknown. In this study, HDDQ dose-dependently inhibited the early stage of RANKL-mediated osteoclast differentiation in bone marrow… CONTINUE READING
    View on PubMed
    doi.org
    13 Citations
    Background Citations
    7
    Methods Citations
    1
    13 Citations
    Citation Type

    Citation Type

    17-Hydroxy-jolkinolide A inhibits osteoclast differentiation through suppressing the activation of NF-κB and MAPKs.
    • 10
    Formononetin attenuates osteoclastogenesis via suppressing the RANKL-induced activation of NF-κB, c-Fos, and nuclear factor of activated T-cells cytoplasmic 1 signaling pathway.
    • 27
    Calycosin Suppresses RANKL-Mediated Osteoclastogenesis through Inhibition of MAPKs and NF-κB
    • 27
    • PDF
    2,4,5-Trimethoxyldalbergiquinol promotes osteoblastic differentiation and mineralization via the BMP and Wnt/β-catenin pathway
    • 44
    • PDF
    Anemonin Attenuates RANKL-Induced Osteoclastogenesis and Ameliorates LPS-Induced Inflammatory Bone Loss in Mice via Modulation of NFATc1
    • 3
    • PDF
    Harpagoside Inhibits RANKL-Induced Osteoclastogenesis via Syk-Btk-PLCγ2-Ca(2+) Signaling Pathway and Prevents Inflammation-Mediated Bone Loss.
    • 20
    Protocatechuic Acid Attenuates Osteoclastogenesis by Downregulating JNK/c‐Fos/NFATc1 Signaling and Prevents Inflammatory Bone Loss in Mice
    • 17
    Massive elimination of multinucleated osteoclasts by eupatilin is due to dual inhibition of transcription and cytoskeletal rearrangement
    • 9
    Tatarinan O, a lignin-like compound from the roots of Acorus tatarinowii Schott inhibits osteoclast differentiation through suppressing the expression of c-Fos and NFATc1.
    • 15
    Tatarinan N inhibits osteoclast differentiation through attenuating NF‐&kgr;B, MAPKs and Ca2+‐dependent signaling
    • 9

    References

    SHOWING 1-10 OF 32 REFERENCES
    c-Fos protein as a target of anti-osteoclastogenic action of vitamin D, and synthesis of new analogs.
    • 96
    • PDF
    Isoliquiritigenin, from Dalbergia odorifera, up-regulates anti-inflammatory heme oxygenase-1 expression in RAW264.7 macrophages
    • 73
    α-Lipoic Acid Inhibits Inflammatory Bone Resorption by Suppressing Prostaglandin E2 Synthesis1
    • 81
    • PDF
    Nuclear Factor of Activated T-cells (NFAT) Rescues Osteoclastogenesis in Precursors Lacking c-Fos*
    • 464
    • PDF
    Akt Induces Osteoclast Differentiation through Regulating the GSK3β/NFATc1 Signaling Cascade
    • 133
    • PDF
    Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families.
    • 2,098
    • PDF
    The phosphatidylinositol 3-kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation.
    • 257
    The molecular understanding of osteoclast differentiation.
    • 978
    Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation
    • 289
    JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms
    • 274
    • PDF