9 Enzymology of Bacterial Lysine Biosynthesis

  title={9 Enzymology of Bacterial Lysine Biosynthesis},
  author={Con Dogovski and Sarah. C. Atkinson and Sudhir R. Dommaraju and Matthew T. Downton and Lilian Hor and S. Moore and Johan Jason and Paxman and Martin G. Peverelli and Theresa Wenli Qiu and Matthias Reumann and Tanzeela Siddiqui and Luc Nicole and Taylor and John Wagner and Jacinta M. Wubben and Matthew A. Perugini},
Lysine is an essential amino acid in the mammalian diet, but can be synthesised de novo in bacteria, plants and some fungi (Dogovski et al., 2009; Hutton et al., 2007). In bacteria, the lysine biosynthesis pathway, also known as the diaminopimelate (DAP) pathway (Fig. 1), yields the important metabolites meso-2,6-diaminopimelate (meso-DAP) and lysine. Lysine is utilised for protein synthesis in bacteria and forms part of the peptidoglycan cross-link structure in the cell wall of most Gram… CONTINUE READING


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