9 Diagnosing Vascular Dementia by Skin Biopsy-Uniqueness of CADASIL

@inproceedings{Tikka20149DV,
  title={9 Diagnosing Vascular Dementia by Skin Biopsy-Uniqueness of CADASIL},
  author={S. B. S. Tikka and Kati Mykk{\"a}nen and Maija Junna and Robert Bergholm and Minna H P{\"o}yh{\"o}nen and Marc Baumann and Matti Viitanen and Hannu O. Kalimo},
  year={2014}
}
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary subcortical vascular dementia. CADASIL is caused by mutations in NOTCH3 gene, which encodes a large transmembrane receptor NOTCH3. The key pathological finding is the accumulation of granular osmiophilic material (GOM), which… CONTINUE READING