9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

@article{Levin19929CisRA,
  title={9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα},
  author={Arthur A. Levin and Laurie J. Sturzenbecker and Sonja Kazmer and Thomas Bosakowski and Christine Huselton and Gary Allenby and Jeffrey Speck and Cl. ratzeisen and Michael Rosenberger and Allen J Lovey and Joseph F. Grippo},
  journal={Nature},
  year={1992},
  volume={355},
  pages={359-361}
}
VITAMIN A (retinol) and its natural derivatives are required for many physiological processes1–3. The activity of retinoids is thought to be mediated by interactions with two subfamilies of nuclear retinoic acid receptors, RAR and RXR. The RARs bind all-trans retinoic acid (t-RA) with high affinity and alter gene expression as a consequence of this direct ligand interaction4–10. RXRα is activated by t-RA, yet has little binding affinity for this ligand (ref. 11) t-RA may be converted to a more… CONTINUE READING
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