8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer

  title={8q24 genetic variation and comprehensive haplotypes altering familial risk of prostate cancer},
  author={William D. Dupont and Joan P. Breyer and W. Dale Plummer and Sam S. Chang and Michael Cookson and Joseph A. Smith and Elizabeth Michael Jessica Deborah Blue Bamshad Chong Nickerson and Elizabeth E. Blue and Michael J. Bamshad and Jessica X. Chong and Deborah A. Nickerson and Elizabeth E. Blue and Michael J. Bamshad and Jeffrey R. Smith},
  journal={Nature Communications},
The 8q24 genomic locus is tied to the origin of numerous cancers. We investigate its contribution to hereditary prostate cancer (HPC) in independent study populations of the Nashville Familial Prostate Cancer Study and International Consortium for Prostate Cancer Genetics (combined: 2,836 HPC cases, 2,206 controls of European ancestry). Here we report 433 variants concordantly associated with HPC in both study populations, accounting for 9% of heritability and modifying age of diagnosis as well… 

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