89Zr-Nanocolloidal Albumin–Based PET/CT Lymphoscintigraphy for Sentinel Node Detection in Head and Neck Cancer: Preclinical Results

@article{Heuveling201189ZrNanocolloidalAP,
  title={89Zr-Nanocolloidal Albumin–Based PET/CT Lymphoscintigraphy for Sentinel Node Detection in Head and Neck Cancer: Preclinical Results},
  author={D. Heuveling and G. Visser and M. Baclayon and W. Roos and G. Wuite and O. Hoekstra and C. Leemans and R. de Bree and G. V. van Dongen},
  journal={The Journal of Nuclear Medicine},
  year={2011},
  volume={52},
  pages={1580 - 1584}
}
Identifying sentinel nodes near the primary tumor remains a problem in, for example, head and neck cancer because of the limited resolution of current lymphoscintigraphic imaging when using 99mTc-nanocolloidal albumin. This study describes the development and evaluation of a nanocolloidal albumin–based tracer specifically dedicated for high-resolution PET detection. Methods: 89Zr was coupled to nanocolloidal albumin via the bifunctional chelate p-isothiocyanatobenzyldesferrioxamine B. Quality… Expand
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