874 ANTI - ALLOANTISERUM AND RECEPTORS Normal Lymphoid Cell

Abstract

I t has been shown previously that antisera raised in (A X B) F~ animals (whereby A and B designate two strains of inbred rats) against alloantibodies A anti-B are capable of specifically blocking the recognition of B antigens by A lymphoid cells (1). The test system used to measure antigenic recognition in vitro was the PAR (product of antigenic recognition) assay (2), basically a short-term mixed lymphocyte culture. The anti-receptor activity of such anti-alloantibodies was indistinguishable, by this test, from that of sera induced in (A X B)F~ rats by the injection of receptor-bearing parental strain lymphoid cells. This led to the conclusion that receptors present on lymphoid cells and those presumed to exist in the antigen-combining region of alloantiserum might be antigenically similar (1).

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Cite this paper

@inproceedings{Binz2003874A, title={874 ANTI - ALLOANTISERUM AND RECEPTORS Normal Lymphoid Cell}, author={Hans Binz and Jean Lindenmann}, year={2003} }