8-pCPT, an Epac activator, impairs conditioned place preference based on nucleus accumbens amphetamine in rats.

@article{Park20148pCPTAE,
  title={8-pCPT, an Epac activator, impairs conditioned place preference based on nucleus accumbens amphetamine in rats.},
  author={Sung Woo Park and Ali Roohbakhsh and Richard J. Beninger},
  journal={Acta neuropsychiatrica},
  year={2014},
  volume={26 2},
  pages={104-11}
}
OBJECTIVES Dopamine receptor-mediated 3',5'-cyclic adenosine monophosphate (cAMP)-dependent intracellular signalling is important for reward-related learning. cAMP activates cAMP-dependent protein kinase (PKA) and exchange protein directly activated by cAMP (Epac). We tested the hypothesis that reward-related learning may be mediated by Epac. METHODS We… CONTINUE READING