8-methoxypsoralen reduces AKT phosphorylation, induces intrinsic and extrinsic apoptotic pathways, and suppresses cell growth of SK-N-AS neuroblastoma and SW620 metastatic colon cancer cells.

@article{Bartnik20178methoxypsoralenRA,
  title={8-methoxypsoralen reduces AKT phosphorylation, induces intrinsic and extrinsic apoptotic pathways, and suppresses cell growth of SK-N-AS neuroblastoma and SW620 metastatic colon cancer cells.},
  author={Magdalena Bartnik and Adrianna Sławińska-Brych and Aleksandra Żurek and Martyna Kandefer-Szerszeń and Barbara Zdzisińska},
  journal={Journal of ethnopharmacology},
  year={2017},
  volume={207},
  pages={19-29}
}
ETHNOPHARMACOLOGICAL RELEVANCE 8-methoxypsoralen (8-MOP) is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juice/fruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. 8-MOP together with UVA light is also used as an anticancer drug for the treatment of cutaneous T-cell lymphoma. However, furanocoumarins exert anticancer activity even without UV irradiation… CONTINUE READING