8-hydroxy-2'-deoxyguanosine and cardiovascular disease: a systematic review.

  title={8-hydroxy-2'-deoxyguanosine and cardiovascular disease: a systematic review.},
  author={Lona J Kroese and Peter G. Scheffer},
  journal={Current atherosclerosis reports},
  volume={16 11},
Oxidative stress due to an excess of reactive oxygen species (ROS) may play a role in the development and progression of cardiovascular disease (CVD). 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a marker of oxidative DNA damage caused by ROS. This review aimed to assess the association between 8-OHdG and CVD by reviewing the literature. Studies in human subjects using either plasma or urine to determine 8-OHdG concentrations were surveyed. Eighteen relevant studies were found, of which 13 were case… CONTINUE READING