8-hydroxy-2'-deoxyguanosine of leukocyte DNA as a marker of oxidative stress in chronic hemodialysis patients.

@article{Tarng20008hydroxy2deoxyguanosineOL,
  title={8-hydroxy-2'-deoxyguanosine of leukocyte DNA as a marker of oxidative stress in chronic hemodialysis patients.},
  author={Der-Cherng Tarng and T P Huang and Yau Huei Wei and Tiffany Yi-Chen Liu and Hsiao Wei Chen and Tzen Wen Chen and Wu Chang Yang},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2000},
  volume={36 5},
  pages={934-44}
}
In contrast to proteins and lipids, oxidative damage to DNA has not been well studied in patients undergoing hemodialysis (HD). We hypothesized that phagocytes are activated after blood-membrane contact during HD, and oxidants from metabolic activation can damage leukocyte DNA. To test this hypothesis, the 8-hydroxy-2'-deoxyguanosine (8-OHdG) content of leukocyte DNA was measured by high-performance liquid chromatography electrochemical detection method in 35 age- and sex-matched healthy… CONTINUE READING
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