8 Regulation of-Synuclein Membrane Binding and Its Implications

  title={8 Regulation of-Synuclein Membrane Binding and Its Implications},
  author={Robert Chien-Chung Chen and Sabine Wislet-Gendebien and Howard T. J. Mount and Anurag Tandon},
1.1 Parkinson’s disease and Lewy bodies Parkinson’s disease (PD) is the most prevalent neurodegenerative disease that affects motor control, although dementia, depression, and other psychiatric symptoms are occasionally present (reviewed in Jankovic, 2008). The motor symptoms include resting tremors, bradykinesia/akinesia, rigidity, and postural instability, and are associated with the death of dopaminergic neurons in the substantia nigra pars compacta (SNpc) (Lloyd and Hornykiewicz, 1970… CONTINUE READING