8-Oxoguanine-DNA glycosylase 1 deficiency modifies allergic airway inflammation by regulating STAT6 and IL-4 in cells and in mice.

@article{Li20128OxoguanineDNAG1,
  title={8-Oxoguanine-DNA glycosylase 1 deficiency modifies allergic airway inflammation by regulating STAT6 and IL-4 in cells and in mice.},
  author={Guoping Li and Kefei Yuan and Chunguang Yan and John L Fox and Madeleine Gaid and Wayne Breitwieser and Arvind K Bansal and Huawei Zeng and Hongwei Gao and Min Wu},
  journal={Free radical biology & medicine},
  year={2012},
  volume={52 2},
  pages={392-401}
}
8-Oxoguanine-DNA glycosylase (OGG-1) is a base excision DNA repair enzyme; however, its function in modulating allergic diseases remains undefined. Using OGG-1 knockout (KO) mice, we show that this protein affects allergic airway inflammation after sensitization and challenge by ovalbumin(OVA). OGG-1 KO mice exhibited less inflammatory cell infiltration and reduced oxidative stress in the lungs after OVA challenge compared to WT mice. The KO phenotype included decreased IL-4, IL-6, IL-10, and… CONTINUE READING

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The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation

International journal of molecular sciences • 2014
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