• DOI:10.1016/j.neuropharm.2003.08.007
Corpus ID: 41623573

8-OH-DPAT as a 5-HT7 agonist: phase shifts of the circadian biological clock through increases in cAMP production

@article{Sprouse20048OHDPATAA,
  title={8-OH-DPAT as a 5-HT7 agonist: phase shifts of the circadian biological clock through increases in cAMP production},
  author={J. Sprouse and L. Reynolds and X. Li and J. Braselton and A. Schmidt},
  journal={Neuropharmacology},
  year={2004},
  volume={46},
  pages={52-62}
}

• J. Sprouse, L. Reynolds, +2 authors A. Schmidt
• Published 2004
• Biology, Medicine
• Neuropharmacology

Neurons in the suprachiasmatic nucleus (SCN), the site of the endogenous biological clock in mammals, fire spontaneously, peaking in firing rate near ZT6 or at the midpoint of the light phase in a 12:12 light-dark cycle. In rat hypothalamic slices, tissue incubations with drugs can produce a shift in this daily rhythm, the magnitude of which is dependent upon dose and the time of treatment. Previous work with 8-OH-DPAT had noted its ability to produce a phase advance, an earlier occurrence of… Expand

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